GTL: This mouse model, also known in the literature as NSG-BLT, is a modification of the BLT mice where cotransplantation is performed on the NSG and not on NOD/SCID background. Since the lifespan of the NSG mice is not curtailed by the development of thymic lymphomas as in the NOD/SCID, the GTL mouse model would potentially allow researchers to carry out longer term experiments than is not possible with the BLT mice.

More information on the development and ongoing research involving different humanized mouse models can be found in the ‘Relevant Literature’ section.