Autoimmunity and tolerance

Graft versus host disease in the bone marrow, liver and thymus humanized mouse model. Greenblatt MB, Vbranac V, Tivey T, Tsang K, Tager AM, Aliprantis AO. PLoS One. 2012;7(9):e44664. doi: 10.1371/journal.pone.0044664. Epub 2012 Sep 5. PMID: 22957096

Xenogeneic graft-versus-host-disease in NOD-scid IL-2R?null mice display a T-effector memory phenotype. Ali N, Flutter B, Sanchez Rodriguez R, Sharif-Paghaleh E, Barber LD, Lombardi G, Nestle FO. PLoS One. 2012;7(8):e44219. doi: 10.1371/journal.pone.0044219. Epub 2012 Aug 28. PMID: 22937164

Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.  Brehm MA, Powers AC, Shultz LD, Greiner DL.  Cold Spring Harb Perspect Med. 2012 May;2(5):a007757.  PMID: 22553498

Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice.  Yi S, Ji M, Wu J, Ma X, Phillips P, Hawthorne WJ, O'Connell PJ.  Diabetes. 2012 Mar 8. [Epub ahead of print]  PMID: 22403295.

Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients.
Waldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, Herold KC.  Sci Transl Med. 2012 Jan 25;4(118):118ra12.  PMID: 22277969

Humanized mice for the study of type 1 and type 2 diabetes.  Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD.  Ann N Y Acad Sci. 2011 Dec;1245:55-8. doi: 10.1111/j.1749-6632.2011.06318.x.  PMID: 22211980

In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates.  Jung KC, Park CG, Jeon YK, Park HJ, Ban YL, Min HS, Kim EJ, Kim JH, Kang BH, Park SP, Bae Y, Yoon IH, Kim YH, Lee JI, Kim JS, Shin JS, Yang J, Kim SJ, Rostlund E, Muller WA, Park SH.  J Exp Med. 2011 Nov 21;208(12):2477-88. Epub 2011 Oct 24.  PMID: 22025302

BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells.  Chang CC, Vlad G, D'Agati VD, Liu Z, Zhang QY, Witkowski P, Torkamani AA, Stokes MB, Ho EK, Cortesini R, Suciu-Foca N.  J Immunol. 2010 Nov 15;185(10):5714-22. Epub 2010 Oct 8.  PMID: 20935202

The humanized NOD/SCID mouse as a preclinical model to study the fate of encapsulated human islets.  Vaithilingam V, Oberholzer J, Guillemin GJ, Tuch BE.  Rev Diabet Stud. 2010 Spring;7(1):62-73. Epub 2010 May 10.  PMID: 20703439